Positive relationships and social connection are essential for human flourishing and thought to be key for long-term happiness, longevity, and wellness. However, utilizing evidence-based systemic therapies alone may not be the solution for everyone, and psychedelics may provide an innovative way to facilitate relational healing.
Ketamine is leading the way as a transformative catalyst to psychotherapy and is being used legally throughout the United States. Ketamine-assisted psychotherapy (KAP) is enhancing mental healthcare, extending its reach from individual treatment into couples and family therapy. Originally created to be used as an anesthetic, ketamine’s profound antidepressant effects and empathy-enhancing properties make it a powerful catalyst for relational healing when used in conjunction with psychotherapy.
The use of ketamine for individual healing has been recognized, however, its relational applications also hold great promise for therapeutic breakthroughs among couples and families. This article explores KAP, its applications in systemic therapies, and offers insights about how it can be used in couples and family therapy for those considering this modern treatment approach for relational healing.
Understanding ketamine: Enhancing mood, empathy, and prosociality
Ketamine is a dissociative anesthetic that acts as an N-methyl-D-aspartate (NMDA) receptor antagonist and induces a dissociative state, which boosts neuroplasticity, empathy, and openness. Ketamine gives one access to an altered state of consciousness, allowing one to receive insights and gain new perspectives. The ability of ketamine to resolve depressive symptoms has been confirmed by Zarate et al. (2006), as it was demonstrated that ketamine has rapid anti-depressive effects, and these findings have continued to be validated by more recent studies, such as the one conducted by Kryst et al. (2020). Through meta-analysis, a single dose of ketamine has been found to have profound antidepressant effects lasting 2 to 3 weeks in clients who experience treatment-resistant depression. Furthermore, repeated ketamine sessions have been shown to be effective in amplifying and sustaining these therapeutic gains (Kryst et al., 2020). Upon administration of ketamine, depressive symptoms resolve within hours. Thus, it holds incredible merit for clients who experience suicidal ideation.
Ketamine has also been found to enhance empathy and prosocial inclinations, which are crucial for relational healing and experiencing a deeper connection with oneself as well as with others. Hess et al. (2024) explored the prosocial, entactogen effects of ketamine, which increased feelings of pleasure from being with others, including family members or close friends. Participants also experienced pleasure from seeing smiling faces and helping others, confirming the prosocial implications of ketamine-assisted psychotherapy (Hess et al., 2024). The prosocial gains from a single dose of ketamine were demonstrated to last one week following the treatment (Hess et al., 2024). Such prosocial effects can help couples and families feel safe in connection and be open to experiencing pleasure from their social interactions. Prosocial shifts and the enhancement of empathy within romantic partners and members of the family unit can be transformative on the relationship as individuals learn new ways of being and relating with each other.
Ketamine-assisted psychotherapy with couples: Reviving communication and connection
Oftentimes, couples face issues with communication and unhealthy relational dynamics. Ketamine-assisted psychotherapy can be used to break these detrimental patterns as romantic partners cultivate more empathy for each other, feel more comfortable being vulnerable, and articulate their needs. Ketamine reduces one’s defenses which helps couples open their hearts, express pain, receive feedback, and build trust.
The cognitive, emotional, and behavioral benefits of ketamine for couples therapy have been proposed by Khalifian et al. (2024). Cognitively, ketamine can help couples have more flexible ways of thinking and release rigid thought patterns due to its neuroplastic effects. Through KAP, couples can learn to take new perspectives on their connection and focus on the positives in their relationships rather than the negatives. Emotionally, ketamine can increase empathy and vulnerability between romantic partners as psychedelic experiences can facilitate greater understanding, acceptance, and feelings of connectedness. Behaviorally, ketamine can improve sexual intimacy and diminish withdrawal as it enhances feelings of reward and pleasure while reducing fear-based avoidance (Khalifian et al., 2024).
Mood changes reported included being less agitated, irritated, angry, and reactive as well as feeling more calm.
Ketamine-assisted psychotherapy has been studied in the context of group couple therapy. Cornfield et al. (2024) used a mixed-methods approach to explore the effects of ketamine administered in four weekly group couple therapy sessions with 18 couples. The quantitative aspect of this study utilized the couples satisfaction index and it was found that there was a significant improvement in these scores following the treatment (Cornfield et al., 2024). The qualitative aspect of this study showed differences in couples’ typical relational dialogue as they cultivated new perspectives, had more insight, increased empathy and compassion for one another, experienced enhanced awareness and vulnerability, and reduction in defensiveness, thus improving their communication and connection (Cornfield et al., 2024). Ketamine’s ability to assist their relational dialogue was referred to as conversational lubricant, as couples felt more open to engage in conversations. The couples also felt changes in their mood, which lasted between a few days to three weeks. Mood changes reported included being less agitated, irritated, angry, and reactive as well as feeling more calm (Cornfield et al., 2024). These results indicate that ketamine may have the potential to be used as a therapeutic catalyst in the context of couple therapy.
Ketamine-assisted psychotherapy with families: Healing intergenerational trauma
Family therapy is complex and attends to the multi-dimensional issues that families face, including intergenerational trauma, ineffective communication, and unhealthy relational patterns. To date, there are no studies exploring the direct use of ketamine-assisted therapy in family therapy, but it can be speculated that the relational gains from this treatment can be applied to the family unit. Such relational gains include: processing unresolved trauma so that it is not playing out in present day or transmitted onto future generations; enhancing emotional empathy, which allows family members to understand and accept each other, and increasing vulnerability, which facilitates family members being heartfelt and engaging in open communication. It is also possible that this treatment will enhance the connection between family members, as this has been seen in studies between romantic partners (Cornfield et al., 2024), and such experiences of connectedness have been conveyed by participants in psychedelic clinical trials. Connectedness includes experiencing a sense of connection with self, others, as well as the universe (Watts et al., 2022). Future research should be devoted to the collective rather than the individual, as this will bring healing not only to families but to society as a whole.
The future of ketamine-assisted psychotherapy in relational contexts
The use of ketamine-assisted psychotherapy within relational contexts is still in its infancy. However, ketamine does hold great promise for couple and family therapy given its unique ability to enhance connection, improve communication, and increase prosocial behaviors—all of which contribute to happy and healthy relationships. As more research is devoted to ketamine-assisted psychotherapy, this therapeutic modality has the potential to become an evidence-based practice. For the time being, KAP remains an innovative treatment for couples and families open to exploring altered states of consciousness in the pursuit of relational healing.

Jen Cahill, PhD, LMFT, is an AAMFT Professional member. She studied couples and family therapy at Nova Southeastern University and specializes in psychedelic integration. https://www.drjencahill.com/
Cornfield, M., McBride, S., La Torre, J. T., Zalewa, D., Gallo, J., Mahammadli, M., & Williams, M. T. (2024). Exploring effects and experiences of ketamine in group couples therapy. Journal of Psychedelic Studies.
Hess, E. M., Greenstein, D. K., Hutchinson, O. L., Zarate, C. A., & Gould, T. D. (2024). Entactogen Effects of Ketamine: A Reverse-Translational Study. The American Journal of Psychiatry, 181(9), 815–823. https://doi.org/10.1176/appi.ajp.20230980
Khalifian, C., Rashkovsky, K., Mitchell, E., Bismark, A., Wagner, A. C., & Knopp, K. C. (2024). A novel framework for ketamine-assisted couple therapy. Front. Psychiatry, 15(1376646). doi: 10.3389/fpsyt.2024.1376646
Kryst, J., Kawalec, P., Mitoraj, A. M., Pilc, A., Lasoń, W., & Brzostek, T. (2020). Efficacy of single and repeated administration of ketamine in unipolar and bipolar depression: a meta-analysis of randomized clinical trials. Pharmacological Reports: PR, 72(3), 543–562. https://doi.org/10.1007/s43440-020-00097-z
Watts, R., Kettner, H., Geerts, D., Gandy, S., Kartner, L., Mertens, L., Timmermann, C., Nour, M., Kaelen, M., Nutt, D. & Carhart‑Harris, R. (2022). The watts connectedness scale: A new scale for measuring a sense of connectedness to self, others, and world. Psychopharmacology, 239, 3461-3483. https://doi.org/10.1007/s00213-022-06187-5
Zarate, C. A. Jr., Singh, J. B., Carlson, P. J., Brutsche, N. E., Ameli, R., Luckenbaugh, D. A., Charney, D. S., Manji, H. K. (2006). A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression. Arch Gen Psychiatry, 63(8), 856-64. doi: 10.1001/archpsyc.63.8.856. PMID: 16894061.
Other articles
Outcomes Framework for Supervision: The Acid-Test
After a century of psychotherapy supervision and over half a century of supervision research, what do we know empirically about the contribution of psychotherapy supervision to patient outcomes (Watkins, 2011; Watkins, 2020; Callahan & Watkins, 2018)? According to reviews conducted by Watkins (2011; 2020), we still don’t know much. This was the conclusion of Watkins after his initial review of 30 years of psychotherapy research (2011).
H. Charles Fishman, MD, Misti Sparks, PhD, & Violeta Kadieva, PhD
Helping Teens Heal from Eating Disorders: Where Family Support, Education, and Recovery Intersect
For families navigating the complexities of an adolescent’s eating disorder diagnosis, treatment decisions often come with difficult trade-offs—including the disruption of their child’s academic progress. School interruptions can heighten a teen’s resistance to treatment, increase family stress, and create barriers to long-term recovery.
Courtney Anderson, MA
Aging out of Therapy: Unique Barriers for the Elderly Accessing Mental Health Services
Aging often brings with it unique challenges in how we experience aspects of our everyday lives. Maintaining one’s health or receiving adequate care for health concerns is often a sign of independence and autonomy. However, what if the same challenges that are characteristic of older age are also barriers to receiving support? Researchers describe the “aging tsunami” as the growing number of individuals living longer while grappling with physical and mental age-related changes.
Denise Williams, PhD